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H. B. D. Prasada Rao, Ph.D.

Scientist-E

Reproductive Biology, Gametogenesis, Oocyte atresia, DNA damage response and repair pathways

prasad[at]niab[dot]org[dot]in
     
Education and training:

Prasad did his M.Sc. (2003) from Andhra University, Vishakhapatnam, and Ph.D. (2011) from Osaka University, Japan. Then he worked as a postdoctoral fellow (2012-2016) at University of California Davis, U.S.A., under the Howard Hughes Medical Institute Investigator Neil Hunter. Later he continued as a post-doctoral research associate (2016-2017) at the same university. He Joined NIAB on 22nd January 2018.


Research experience and interests

Prasad’s research experience spans molecular genetics and reproductive biology, particularly regulation of gametogenesis in males and females by post-translational modifications such as phosphorylation, SUMOylation, ubiquitination, and proteolysis to produce haploid gametes. His interests are in understanding errors in gametogenesis which lead to infertility, pregnancy miscarriages, and congenital diseases. The focus of his research at NIAB are to understand (a) the quality control pathways in oocyte and spermatocyte development to extend livestock fertility, (b) molecular mechanisms of meiotic processes, such as homologous recombination and synapses in livestock to increase the fecundity and to prevent birth defects, (c) causes and treatments of ovarian disorders in livestock, and (d) genome instability and DNA repair pathways.


Selected awards and fellowships
  1. Ramalingaswami Re-entry Fellowship (DBT, Govt. of India, 2017)

  2. Post-doctoral fellowship: Howard Hughes Medical Institute, USA (2012-2017)

  3. Japanese Government Monbukagakusho (MEXT) scholarship (2007-2011)

  4. R99 Industrial Fellowship, Japan (2008-2009)

  5. JASSO Fellowship, Japan (2008- 2010)

Membership of Professional Societies
  1. Genetics Society of America, GSA, Member (2013-2017)

  2. The molecular biology society of Japan, MBSJ, Member (2007-2013)

Selected Publications
  1. Huanyu Qiao*, H.B.D. Prasada Rao*, Michael Nguyen, Jared H.Fong, Manali Sarpe, Benjamin W. Van, Amy Lee, Tiffany.Y.H.Chng, Kevin Zang, Neil Hunter. (2017). RNF212 Impedes DNA Break Repair to Enable Post-Partum Oocyte Quality Control. In revision with. Molecular cell, * Co-first author

  2. H.B.D. Prasada Rao, Huanyu Qiao, Shubhang K. Bhatt, Logan R.J. Bailey, Hung D. Tran, Sarah L. Bourne, Wendy Qiu, Anusha Deshpande, Ajay N. Sharma, Connor J. Beebout, Roberto J. Pezza and Neil Hunter (2017). A SUMO-Ubiquitin Relay Recruits Proteasomes to Chromosome Axes to Regulate Meiotic Recombination. Science, 27 Jan 2017: Vol. 355, Issue 6323, pp. 403-407

  3. H Qiao, H.B.D. Prasada Rao, Ye Yang, Jared H. Fong, Jeffrey M. Cloutier, Dekker C. Deacon, Kathryn E. Nagel, Rebecca K. Swartz, Edward Strong, J. Kim Holloway, John Schimenti, Jeremy Ward, Neil Hunter. (2014). Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nature Genetics, 46(2): 194-199

  4. Gyanalok Das, Pradeep Naik, M Bordoloi, HBD Prasada Rao, P.Das "Typhonium trilobatum (L.) Schott shows Potency against Lymphatic Filariasis in Man. International Journal of Indigenous Medicinal Plants, May 2015, ISSN: 2051-4263, Vol.48, Issue.1

  5. H.B.D.Prasada Rao, Miki Shinohara, Akira Shinohara, The Mps3 SUN domain is important for chromosome motion and juxtaposition of homologous chromosomes during meiosis. Genes to cells, (2011) 16, 1081–1096

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