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Areas of Specialization:

H. B. D. Prasada Rao, Ph.D.


Reproductive Biology, Gametogenesis, Oocyte atresia, DNA damage response and repair pathways

Education and training:

Prasad did his M.Sc. (2003) from Andhra University, Vishakhapatnam, and Ph.D. (2011) from Osaka University, Japan. Then he worked as a postdoctoral fellow (2012-2016) at University of California Davis, U.S.A., under the Howard Hughes Medical Institute Investigator Neil Hunter. Later he continued as a post-doctoral research associate (2016-2017) at the same university. He Joined NIAB on 22nd January 2018.

Research experience and interests

Prasad’s research experience spans molecular genetics and reproductive biology, particularly regulation of gametogenesis in males and females by post-translational modifications such as phosphorylation, SUMOylation, ubiquitination, and proteolysis to produce haploid gametes. His interests are in understanding errors in gametogenesis which lead to infertility, pregnancy miscarriages, and congenital diseases. The focus of his research at NIAB are to understand (a) the quality control pathways in oocyte and spermatocyte development to extend livestock fertility, (b) molecular mechanisms of meiotic processes, such as homologous recombination and synapses in livestock to increase the fecundity and to prevent birth defects, (c) causes and treatments of ovarian disorders in livestock, and (d) genome instability and DNA repair pathways.

Selected awards and fellowships
  1. Ramalingaswami Re-entry Fellowship (DBT, Govt. of India, 2017)

  2. Post-doctoral fellowship: Howard Hughes Medical Institute, USA (2012-2017)

  3. Japanese Government Monbukagakusho (MEXT) scholarship (2007-2011)

  4. R99 Industrial Fellowship, Japan (2008-2009)

  5. JASSO Fellowship, Japan (2008- 2010)

Membership of Professional Societies
  1. Genetics Society of America, GSA, Member (2013-2017)

  2. The molecular biology society of Japan, MBSJ, Member (2007-2013)

Selected Publications
  1. Anastasiia Bondarieva, Kavya Raveendran, Vladyslav Telychko, H. B. D. Prasada Rao, Ramya Ravindranathan, Chrysoula Zorzompokou, Friederike Finsterbusch, Ihsan Dereli, Frantzeskos Papanikos, Daniel Tränkner, Alexander Schleiffer, Ji-Feng Fei, Anna Klimova, Masaru Ito, Dhananjaya S. Kulkarni, Ingo Roeder, Neil Hunter & Attila Tóth; Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse. Nature communications, June 11, 3101 (2020)

  2. Wei He, H.B.D.Prasada Rao, Shangming Tang, Nikhil Bhagwat, Dhananjaya Kulkarni, Yunmei Ma, MariaA.W. Chang, Christie Hall, Junxi Wang, HarrisonS. Manacsa, Christ a Baker, GerrikF. Verhees, Lepakshi Singh, Xiangyu Chen, NancyM. Hollingsworth, Petr Cejka, Neil Hunter; Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over. Mol.cell, 2020 Apr 2;78(1):168-183

  3. Huanyu Qiao*, H.B.D. Prasada Rao*, Michael Nguyen, Jared H.Fong, Manali Sarpe, Benjamin W. Van, Amy Lee, Tiffany.Y.H.Chng, Kevin Zang, Neil Hunter; RNF212 Impedes DNA Break Repair to Enable Post-Partum Oocyte Quality Control. Mol.Cell. 2018 Oct 18;72(2):211-221.e3 (* Co first author)

  4. H.B.D. Prasada Rao, Huanyu Qiao, Shubhang K. Bhatt, Logan R.J. Bailey, Hung D. Tran, Sarah L. Bourne, Wendy Qiu, Anusha Deshpande, Ajay N. Sharma, Connor J. Beebout, Roberto J. Pezza and Neil Hunter (2017). A SUMO-Ubiquitin Relay Recruits Proteasomes to Chromosome Axes to Regulate Meiotic Recombination. Science, 27Jan 2017: Vol. 355, Issue 6323, pp. 403-407

  5. H Qiao, H.B.D. Prasada Rao, Ye Yang, Jared H. Fong, Jeffrey M. Cloutier, Dekker C. Deacon, Kathryn E. Nagel, Rebecca K. Swartz, Edward Strong, J. Kim Holloway, John Schimenti, Jeremy Ward, Neil Hunter. (2014). Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nature Genetics, 46(2): 194-199

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Mission: Development of sustainable and  globally competitive livestock industry through innovative technology.

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